Heterotypic communication as the promoter of phenotypic plasticity of cancer cells: The role of cancer secretomes

Autor(es)

Zelanis, Andre ; Barcick, Uilla ; Racorti, Nathalia de Vasconcellos ; Salardani, Murilo

• Tipo de documento: Artigo Científico
• Fonte: PROTEOMICS; v. N/A, p. 10-pg., 2023-07-20.

Resumo

Cellular communication relies on signaling circuits whose statuses are mainly modulated by soluble biomolecules such as carbohydrates, lipids, proteins, and metabolites as well as extracellular vesicles (EVs). Therefore, the active secretion of such biomolecules is critical for both cell homeostasis and proper pathophysiological responses in a timely fashion. In this context, proteins are among the main modulators of such biological responses. Hence, profiling cell line secretomes may be an opportunity for the identification of "signatures" of specific cell types (i.e., stromal or metastatic cells) with important prognostic/therapeutic value. This review will focus on the biological implications of cell secretomes in the context of cancer, as well as their functional roles in shaping the tumoral microenvironment (TME) and communication status of participating cells. (AU)

• Processo FAPESP: 21/05087-3 - Avaliação do efeito da sinalização heterotípica na modulação do fenótipo tumoral em Melanoma
• Beneficiário: Uilla Barcick
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/07282-8 - Prospecção de marcadores associados a processamento proteolítico em amostras de plasma de pacientes com melanoma
• Beneficiário: André Zelanis Palitot Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular