Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis

Autor(es)

Victorino, Daniella B. ; Faber, Jean ; Pinheiro, Daniel J. L. L. ; Scorza, Fulvio A. ; Almeida, Antonio C. G. ; Costa, Alberto C. S. ; Scorza, Carla A.

• Tipo de documento: Artigo Científico
• Fonte: Aging and disease; v. 14, n. 2, p. 22-pg., 2023-04-01.

Resumo

Cross-frequency coupling (CFC) mechanisms play a central role in brain activity. Pathophysiological mechanisms leading to many brain disorders, such as Alzheimer's disease (AD), may produce unique patterns of brain activity detectable by electroencephalography (EEG). Identifying biomarkers for AD diagnosis is also an ambition among research teams working in Down syndrome (DS), given the increased susceptibility of people with DS to develop early-onset AD (DS-AD). Here, we review accumulating evidence that altered theta-gamma phase-amplitude coupling (PAC) may be one of the earliest EEG signatures of AD, and therefore may serve as an adjuvant tool for detecting cognitive decline in DS-AD. We suggest that this field of research could potentially provide clues to the biophysical mechanisms underlying cognitive dysfunction in DS-AD and generate opportunities for identifying EEG-based biomarkers with diagnostic and prognostic utility in DS-AD. (AU)

• Processo FAPESP: 16/17746-3 - Avaliação dos efeitos de benzodiazepínicos sobre a atividade eletrofisiológica cerebral in vivo e a viabilidade neuronal in vitro em camundongos da linhagem Ts65Dn
• Beneficiário: Daniella Balduino Victorino
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/10131-9 - Efeitos da modulação alostérica positiva sobre as propriedades eletrofisiológicas da sinalização mediada por receptores GABAA em camundongos Ts65Dn e neurônios derivados de células-tronco pluripotentes induzidas de pessoas com a síndrome de Down
• Beneficiário: Daniella Balduino Victorino
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado