Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options

Autor(es)

Alves, Erick Tavares Marcelino ; Pernichelle, Filipe Gomes ; Nascimento, Lucas Adriano ; Ferreira, Glaucio Monteiro ; Ferreira, Elizabeth Igne

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICALS; v. 16, n. 7, p. 40-pg., 2023-07-01.

Resumo

Neglected diseases, primarily found in tropical regions of the world, present a significant challenge for impoverished populations. Currently, there are 20 diseases considered neglected, which greatly impact the health of affected populations and result in difficult-to-control social and economic consequences. Unfortunately, for the majority of these diseases, there are few or no drugs available for patient treatment, and the few drugs that do exist often lack adequate safety and efficacy. As a result, there is a pressing need to discover and design new drugs to address these neglected diseases. This requires the identification of different targets and interactions to be studied. In recent years, there has been a growing focus on studying enzyme covalent inhibitors as a potential treatment for neglected diseases. In this review, we will explore examples of how these inhibitors have been used to target Human African Trypanosomiasis, Chagas disease, and Malaria, highlighting some of the most promising results so far. Ultimately, this review aims to inspire medicinal chemists to pursue the development of new drug candidates for these neglected diseases, and to encourage greater investment in research in this area. (AU)

• Processo FAPESP: 20/13347-2 - Antichagásicos potenciais: planejamento e síntese de híbridos moleculares de inibidores das enzimas fe-superóxido dismutase e CYP51 com liberadores de óxido nítrico
• Beneficiário: Filipe Gomes Pernichelle
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 21/04778-2 - Antichagásico potencial: planejamento e síntese de híbrido molecular de inibidor das enzimas Fe-syperóxido dismutase e CYP51 com liberador de óxido nítrico
• Beneficiário: Erick Tavares Marcelino Alves
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica