In vitro studies of the antibacterial activity of Copaifera spp. oleoresins, sodium hypochlorite, and peracetic acid against clinical and environmental isolates recovered from a hemodialysis unit

Autor(es)

Vieira, Rosimara Goncalves Leite ; Moraes, Thais da Silva ; Silva, Larissa de Oliveira ; Bianchi, Thamires Chiquini ; Veneziani, Rodrigo Cassio Sola ; Ambrosio, Sergio Ricardo ; Bastos, Jairo Kenupp ; Pires, Regina Helena ; Martins, Carlos Henrique Gomes

• Tipo de documento: Artigo Científico
• Fonte: ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL; v. 7, n. 1, p. 13-pg., 2018-01-24.

Resumo

BackgroundPatients submitted to hemodialysis therapy are more susceptible to infection, especially to infection by Gram-positive bacteria. Various research works have attempted to discover new antimicrobial agents from plant extracts and other natural products.MethodsThe present study aimed to assess the antibacterial activities of Copaifera duckei, C. reticulata, and C. oblongifolia oleoresins; sodium hypochlorite; and peracetic acid against clinical and environmental isolates recovered from a Hemodialysis Unit. The Minimum Inhibitory Concentration and the Fractionated Inhibitory Concentration Index were determined; the ability of the tested compounds/extracts to inhibit biofilm formation was evaluated by calculating the MICB50 and IC50.ResultsC. duckei was the most efficient among the assayed Copaifera species, and its oleoresin was more effective than peracetic acid and sodium hypochlorite. Copaifera oleoresins and disinfectants did not act synergistically at any of the tested combinations. Certain of C. duckei oleoresin, peracetic acid, and sodium hypochlorite concentrations inhibited biofilm formation and eradicated 50% of the biofilm population.ConclusionC. duckei oleoresin is a potential candidate for disinfectant formulations. Based on these results and given the high incidence of multi-resistant bacteria in hemodialysis patients, it is imperative that new potential antibacterial agents like C. duckei oleoresin, which is active against Staphylococcus, be included in disinfectant formulations. (AU)

• Processo FAPESP: 11/13630-7 - Validação química e farmacológica de extratos e princípios ativos de espécies de Copaifera
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/25237-0 - Diterpenos do tipo caurano: atividade antibacteriana frente a bactérias anaeróbias e análise proteômica
• Beneficiário: Carlos Henrique Gomes Martins
• Modalidade de apoio: Auxílio à Pesquisa - Regular