| Texto completo | |
| Autor(es): |
Tanaka, Denise Mayumi
;
Simoes, Marcus Vinicius
;
Marin-Neto, Jose Antonio
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EXPERT REVIEW OF CARDIOVASCULAR THERAPY; v. 21, n. 6, p. 9-pg., 2023-05-25. |
| Resumo | |
Introduction: Myocardial ischemia is common in patients with chronic Chagas cardiomyopathy (CCC), but only recently clinical and experimental studies highlighted the involvement of this abnormality as contributing to the progression of myocardial damage. Areas covered: Despite the absence of obstructive epicardial coronary artery disease at angiography, and limited evidence of abnormal flow regulation at the macrovascular level, remarkable functional and structural microvascular abnormalities are consistently reported by independent investigations of CCC. These derangements occur early and contribute to myocardial dysfunction. Recent research focused on reversing microvascular dysfunction as a target to positively impact the course of CCC. We conducted an extensive review of the scientific literature, aiming to summarize the role of coronary dysfunction causing myocardial ischemia in CCC, with a focus on implications for clinical management of individuals affected by this disease. Expert Opinion: Preclinical studies showed a clear correlation between perfusion defects and inflammation in viable but impaired dysfunctional myocardium. These findings provided further insight into the CCC complex pathophysiology and support the role of very few recent therapeutic interventions aiming to relieve myocardial ischemia. Further research is warranted to assess the efficacy of new interventions addressing reversal of microvascular ischemia and inflammation modulation and halting ventricular dysfunction progression in CCC. (AU) | |
| Processo FAPESP: | 17/16450-6 - Efeito do uso prolongado de pentoxifilina sobre as alterações perfusionais miocárdicas, eventos arrítmicos e a evolução da disfunção sistólica ventricular esquerda na cardiomiopatia chagásica crônica |
| Beneficiário: | Marcus Vinicius Simões |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/25403-9 - Investigações sobre etiopatogenia, fisiopatologia e terapêutica em humanos e em modelo experimental com a cardiomiopatia da Doença de Chagas |
| Beneficiário: | José Antonio Marin-Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/21250-1 - Cardiomiopatia Chagásica Crônica em modelo experimental animal: estudo prospectivo das alterações anatômicas e funcionais ventriculares e do efeito de intervenções terapêuticas |
| Beneficiário: | Denise Mayumi Tanaka |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |