| Texto completo | |
| Autor(es): |
Kawassaki, Rodrigo Ken
;
Romano, Mariana
;
Uchiyama, Mayara Klimuk
;
Cardoso, Roberta Mansini
;
Baptista, Mauriicio S.
;
Farsky, Sandra H. P.
;
Chaim, Khallil Taverna
;
Guimaraes, Robson Raphael
;
Araki, Koiti
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Nano Letters; v. 23, n. 12, p. 9-pg., 2023-06-10. |
| Resumo | |
Nanostructured contrast agents are promising alternativesto Gd3+-based chelates in magnetic resonance (MR) imagingtechniques.A novel ultrasmall paramagnetic nanoparticle (UPN) was strategicallydesigned to maximize the number of exposed paramagnetic sites and r (1) while minimizing r (2), by decorating 3 nm titanium dioxide nanoparticles with suitableamounts of iron oxide. Its relaxometric parameters are comparableto those of gadoteric acid (GA) in agar phantoms, and the r (2)/r (1) ratio of 1.38at 3 T is close to the ideal unitary value. The strong and prolongedcontrast enhancement of UPN before renal excretion was confirmed by T (1)-weighted MR images of Wistar rats after intravenousbolus injection. Those results associated with good biocompatibilityindicate its high potential as an alternative blood-pool contrastagent to the GA gold standard for MR angiography, especially for patientswith severe renal impairment. (AU) | |
| Processo FAPESP: | 09/54323-0 - Plataforma de imagem na sala de autópsia |
| Beneficiário: | Paulo Hilário Nascimento Saldiva |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa Equipamentos Multiusuários |
| Processo FAPESP: | 18/21489-1 - Nanotecnologia supramolecular: design, materiais e dispositivos |
| Beneficiário: | Henrique Eisi Toma |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/02151-2 - Desenvolvimento de nanoagente teranóstico bimodal para MRI e PET/SPECT |
| Beneficiário: | Rodrigo Ken Kawassaki |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |