| Texto completo | |
| Autor(es): |
Esteves, Gabriel P.
;
Swinton, Paul
;
Sale, Craig
;
Gualano, Bruno
;
Roschel, Hamilton
;
Dolan, Eimear
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Applied Physiology; v. 135, n. 1, p. 8-pg., 2023-07-01. |
| Resumo | |
Bone mass and quality decline with age, and can culminate in osteoporosis and increased fracture risk. This investigation modeled associations between bone and physical, dietary, and metabolic factors in a group of 200 pre-frail/frail older adults using factor analysis and structural equation modeling (SEM). Exploratory (EFA) and confirmatory factor analysis (CFA) were conducted to compose factors and to assess their robustness. SEM was used to quantify associations between bone and the other factors. Factors arising from EFA and CFA were: bone (whole body, lumbar and femur bone mineral density, and trabecular bone score; good fit), body composition - lean (lean mass, body mass, vastus lateralis, and femoral cross-sectional area; good fit), body composition - fat (total fat mass, gynoid, android, and visceral fat; acceptable fit), strength (bench and leg press, handgrip, and knee extension peak torque; good fit), dietary intake (kilocalories, carbohydrate, protein, and fat; acceptable fit), and metabolic status (cortisol, insulin-like growth factor 1 (IGF-1), growth hormone (GH), and free testosterone; poor fit). SEM using isolated factors showed that body composition (lean) (13 = 0.66, P < 0.001), body composition (fat) (13 = 0.36, P < 0.001), and strength (13 = 0.74, P < 0.001) positively associated with bone. Dietary intake relative to body mass negatively associated with bone (13 = -0.28, P = 0.001), whereas in absolute terms, it showed no association (13 = 0.01, P = 0.911). In a multivariable model, only strength (13 = 0.38, P = 0.023) and body composition (lean) (13 = 0.34, P = 0.045) associated with bone. Resistance training programs that focus on improving lean mass and strength in older individuals may benefit bone in this population. (AU) | |
| Processo FAPESP: | 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health |
| Beneficiário: | Bruno Gualano |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/05616-6 - A resposta óssea ao exercício: um programa de pesquisa translacional explorando aspectos clínicos e mecanísticos |
| Beneficiário: | Eimear Bernadette Dolan |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 20/07860-9 - A influência do treinamento físico na saúde óssea de pacientes recebendo doses elevadas de glicocorticoides |
| Beneficiário: | Gabriel Perri Esteves |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/26899-6 - A resposta óssea ao exercício: um programa de pesquisa translacional explorando aspectos clínicos e mecanísticos |
| Beneficiário: | Eimear Bernadette Dolan |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |