Eight-year change in carotid intima-media thickness and associated risk factors in adults with and without psoriasis - the ELSA-Brasil cohort study

Autor(es)

Tebar, W. R. ; Santos, I. S. ; Meneghini, V. ; Bittencourt, M. S. ; Lotufo, P. A. ; Bensenor, I. M.

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 56, n. 1, p. 11-pg., 2023-01-01.

Resumo

The longitudinal association between psoriasis and carotid intima-media thickness (CIMT) has not yet been established. This study aimed do compare CIMT and its change (ACIMT) after an 8-year follow-up according to psoriasis diagnosis and the association with risk factors in the ELSA-Brasil study. Data from 7564 participants were analyzed (median age of 50.0 [44.0-57.0] years, 56.9% women). CIMT was assessed by ultrasound and ACIMT was calculated by subtracting baseline values from follow-up values. Psoriasis participants were identified by self-reported medical diagnosis (n=143) and compared with matched participants without disease (n=572) and with the entire sample without psoriasis (n=7421). Baseline CIMT explained the 8-year CIMT increase only in 36.9% among psoriasis participants and in B43.0% in participants without disease. CIMT was associated with age (6=0.002, P=0.002) and hypertension (6=0.029, P=0.034) in psoriasis participants. Among participants without psoriasis, CIMT was associated with age, male sex, low educational attainment, past smoking, obesity, diabetes, hypertension, and dyslipidemia (P<0.05). There was an inverse association of CIMT with private health insurance (6=-0.004, P=0.042) and White ethnicity (6=-0.006, P=0.004) in the entire sample without psoriasis but not in matched participants. Psoriasis participants showed an inverse association between ACIMT and diabetes (6=-0.214, P=0.011), while the entire sample without psoriasis showed an inverse association between ACIMT and age (6=-0.005, P<0.001), past smoking (6=-0.048, P=0.009), and hypertension (6=-0.048, P=0.009). In conclusion, psoriasis was not associated with CIMT after an 8-year follow-up. The inverse association of ACIMT with diabetes in psoriasis participants needs further clarification. (AU)

• Processo FAPESP: 19/23734-6 - Doenças inflamatórias crônicas e mortalidade geral, por doença cardiovascular e outras causas: associação com fatores de risco, Aterosclerose subclínica e eventos cardiovasculares fatais e não fatais no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/04416-3 - Associação de Lúpus, Síndrome de Sjögren, Vasculites, Doença Celíaca e Psoríase com escore de cálcio na linha de base e incidência/progressão de escore de cálcio, mortalidade geral e por doença cardiovascular no seguimento de 8 anos do ELSA-Brasil
• Beneficiário: William Rodrigues Tebar
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/06798-0 - Doença tireoidiana autoimune e doenças inflamatórias: associação com a Aterosclerose subclínica e com mortalidade geral e por doenças cardiovasculares no ELSA-Brasil
• Beneficiário: Vandrize Meneghini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado