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Cystic Fibrosis: A Descriptive Analysis of Deaths in a Two-Decade Period in Brazil According to Age, Race, and Sex

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Autor(es):
de Azevedo, Luan Victor Frota ; Cruz, Fernanda Cristine Ribeiro Medeiros ; Martins, Jessica Paula ; Marson, Fernando Augusto Lima
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: DIAGNOSTICS; v. 13, n. 4, p. 16-pg., 2023-02-01.
Resumo

The diagnosis of cystic fibrosis has improved in the last few years due to greater access to diagnostic tools and the evolution of molecular biology; the knowledge obtained has contributed to the understanding of its death profile. In this context, an epidemiological study was developed focusing on deaths from cystic fibrosis in Brazil from 1996 to 2019. The data were collected from the Data-SUS (Unified National Health System Information Technology Department from Brazil). The epidemiological analysis included patients' age groups, racial groups, and sex. In our data, between 1996 and 2019, sigma 3050 deaths were recorded, totaling a approximately equal to 330% increase in the number of deaths resulting from cystic fibrosis. This fact might be related to a better diagnosis of the disease, mainly in patients from racial groups that are not commonly associated with cystic fibrosis, such as Black individuals, Hispanic or Latino (mixed individuals/Pardos) individuals, and American Indians (Indigenous peoples from Brazil). Regarding of race, the sigma of deaths was: nine (0.3%) in the American Indian group, 12 (0.4%) in the Asian group, 99 (3.6%) in the Black or African American group, 787 (28.6%) in the Hispanic or Latino group, and 1843 (67.0%) in the White group. The White group showed the highest prevalence of deaths, and the increase in mortality was approximately equal to 150 times in this group, while, in the Hispanic or Latino group, it was approximately equal to 75 times. Regarding sex, the numbers and percentage of deaths of both male (N = 1492; 48.9%) and female (N = 1557; 51.1%) patients were seen to be relatively close. As for age groups, the >60-year-old group presented the most significant results, with an increase of approximately equal to 60 times in the registered deaths. In conclusion, in Brazil, despite the number of deaths from cystic fibrosis being prevalent in the White group, it increased in all racial groups (Hispanic or Latino, Black or African American, American Indian, or Asian individuals) and was associated with older age. (AU)

Processo FAPESP: 20/03342-3 - Caracterização do teste do suor no Brasil: um estudo epidemiológico
Beneficiário:Luan Victor Frota de Azevedo
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica