| Texto completo | |
| Autor(es): |
Martins-Santana, Leonardo
;
Rezende, Caroline Patini
;
Rossi, Antonio
;
Martinez-Rossi, Nilce Maria
;
Almeida, Fausto
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PATHOGENS; v. 12, n. 2, p. 15-pg., 2023-02-01. |
| Resumo | |
Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing a bottleneck in treating affected people. Resistant fungi are an emergent public health threat. The upsurge of such pathogens has led to new research toward unraveling the destructive potential evoked by these species. Some fungi-grouped into Candida, Aspergillus, and Cryptococcus-are causative agents of severe and systemic infections. They are associated with high mortality rates and have recently been described as sources of coinfection in COVID-hospitalized patients. Despite the efforts to elucidate the challenges of colonization, dissemination, and infection severity, the immunopathogenesis of fungal diseases remains a pivotal characteristic in fungal burden elimination. The struggle between the host immune system and the physiological strategies of the fungi to maintain cellular viability is complex. In this brief review, we highlight the relevance of drug resistance phenotypes in fungi of clinical significance, taking into consideration their physiopathology and how the scientific community could orchestrate their efforts to avoid fungal infection dissemination and deaths. (AU) | |
| Processo FAPESP: | 21/06794-5 - Vesículas extracelulares fúngicas: imunomodulação e comunicação celular |
| Beneficiário: | Fausto Bruno dos Reis Almeida |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 19/22596-9 - Mecanismos moleculares associados à patogenicidade e resistência em fungos: estratégias para o tratamento de dermatofitoses |
| Beneficiário: | Nilce Maria Martinez-Rossi |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 21/10255-2 - Fatores de transcrição e vias de sinalização celular na patogenicidade e modulação da resposta imune |
| Beneficiário: | Leonardo Martins Santana |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 20/03215-1 - Identificação e caracterização de vesículas extracelulares fúngicas em pacientes com Candidíase, Criptococose e Paracoccidioidomicose |
| Beneficiário: | Caroline Patini de Rezende |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |