| Texto completo | |
| Autor(es): |
Ruiz, Thalles F. R.
;
Grigio, Vitor
;
Ferrato, Luara J.
;
de Souza, Lorena G.
;
Colleta, Simone J.
;
Amaro, Gustavo M.
;
Goes, Rejane M.
;
Vilamaior, Patricia S. L.
;
Leonel, Ellen C. R.
;
Taboga, Sebastia O. R.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecular and Cellular Endocrinology; v. 566, p. 11-pg., 2023-03-06. |
| Resumo | |
The ovaries regulate fertility and hormonal control in females, and aging is a crucial factor in this process, when ovarian function is drastically impacted. Exogenous endocrine disruptors may accelerate this process, acting as the main agents in decreased female fertility and hormonal imbalance, since they impact different features related to reproduction. In the present study, we demonstrate the implications of exposure of adult mothers to the endocrine disruptor bisphenol A (BPA) during pregnancy and lactation on their ovarian function during the transition to later in life (aging). The follicle population of BPA exposed ovaries showed impairment in the development of follicles to the mature stages, with growing follicles being halted in the early stages. Atretic and early-atretic follicles were also enhanced. Expression of estrogen and androgen receptors in the follicle population demonstrated impairment in signaling function: ER8 was highly expressed in follicles from BPA exposed females, which also showed a higher incidence of early atresia of developed follicles. ER81 wild-type isoform was also enhanced in BPA-exposed ovaries, compared to its variant isoforms. In addition, steroidogenesis was targeted by BPA exposure: aromatase and 17-8-HSD were reduced, whereas 5-alpha reductase was enhanced. This modulation was reflected in serum levels of estradiol and testosterone, which decreased in BPA-exposed females. Imbalances in steroidogenesis impair the development of follicles and play an important role in follicular atresia. Our study demonstrated that BPA exposure in two windows of susceptibility - gestation and lactation - had implications during aging, enhancing perimenopausal and infertile features. (AU) | |
| Processo FAPESP: | 21/14140-5 - Impactos das terapias hormonais na glândula mamária e próstata de fêmeas envelhecidas sob a influência do desregulador endócrino bisfenol A |
| Beneficiário: | Sebastião Roberto Taboga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/00521-0 - Carcinogênese mamária em fêmeas senis induzida por Bisfenol A: influência de terapias hormonais no desenvolvimento neoplásico |
| Beneficiário: | Thalles Fernando Rocha Ruiz |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 18/23383-6 - Repercussões histopatológicas da ação dos desreguladores endócrinos bisfienol-A e 17-beta-estradiol sobre glândulas mamárias e próstata feminina do Gerbilo da Mongólia e suas relações com a carcinogênese quimicamente induzida pelo MNU |
| Beneficiário: | Sebastião Roberto Taboga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/00160-1 - Efeitos da exposição materna ao bisfenol A sobre próstata de gerbilos (Meriones unguiculatus) adultos e senescentes |
| Beneficiário: | Simone Jacovaci Colleta |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/01240-9 - Efeitos tardios da exposição ao bisfenol A na mama de fêmeas de gerbilos durante o período gestacional e lactacional |
| Beneficiário: | Thalles Fernando Rocha Ruiz |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |