Busca avançada
Ano de início
Entree


Short-chain fatty acids are associated with adiposity, energy and glucose homeostasis among different metabolic phenotypes in the Nutritionists' Health Study

Texto completo
Autor(es):
Mostrar menos -
Solar, Isabela ; Ribeiro, Francieli Barreiro ; Barbosa, Marina Gomes ; Freitas, Renata Germano Borges de Oliveira Nascimento ; Hanada, Alfredo Shigueo ; Ramos, Camila de Oliveira ; Sant'Ana, Marcella Ramos ; Candreva, Thamiris ; de Almeida-Pititto, Bianca ; Tura, Andrea ; Cintra, Dennys Esper ; Geloneze, Bruno ; Ferreira, Sandra Roberta Gouvea ; Vasques, Ana Carolina Junqueira
Número total de Autores: 14
Tipo de documento: Artigo Científico
Fonte: ENDOCRINE; v. 80, n. 3, p. 12-pg., 2023-04-08.
Resumo

Background and aimsThe gut microbiome is associated with obesity, mainly mediated by bacteria-produced short-chain fatty acids (SCFAs). It is unknown how SCFA concentrations are associated with the phenotypes metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy obese/overweight (MHO), and metabolically unhealthy obese/overweight (MUO). We compared plasma and fecal SCFA concentrations among adult women categorized according to the metabolic phenotypes mentioned above and examined associations between SCFA and adiposity and components of energy and glucose homeostasis.MethodsThis was a cross-sectional study involving 111 participants. Body composition was assessed by DEXA. Energy and glycemic homeostasis were assessed by the standard mixed-meal tolerance test coupled with indirect calorimetry. SCFAs were quantified by gas chromatography and mass spectrometry.ResultsOnly plasma propionate was increased in the MHNW phenotype compared to the MHO and MUO phenotypes [p < 0.05]. Fecal propionate and butyrate concentrations and plasma propionate concentrations were inversely associated with total and visceral adiposity [p < 0.05]. Fecal and plasma SCFA concentrations were associated with reduced glucose, insulin and HbA1c levels, increased fasting and postprandial GLP-1 levels; and more preserved beta-cell function [p < 0.05]. Fecal and plasma SCFA concentrations were positively correlated with resting energy expenditure and lipid oxidation rate and inversely correlated with the oxidation rate of carbohydrates [p < 0.05].ConclusionThese findings reinforce the concept that fecal and plasma SCFA concentrations are linked to specific components of energy and glucose homeostasis; and body adiposity. However, it was not possible to discriminate the different metabolic phenotypes of adiposity based on the determination of fecal SCFA concentrations. (AU)

Processo FAPESP: 17/10185-9 - Fenótipos metabólicos da obesidade: associações com ácidos graxos de cadeia curta e componentes das homeostases energética e glicêmica no Nutritionists Health Study - NutriHS
Beneficiário:Ana Carolina Junqueira Vasques
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/07769-4 - Fenótipos Metabólicos da Obesidade: Associações com Ácidos Graxos de Cadeia Curta e Componentes das Homeostases Energética e Glicêmica no Nutritionists Health Study - NutriHS
Beneficiário:Alfredo Shigueo Hanada
Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
Processo FAPESP: 17/24578-2 - Ácidos graxos de cadeia curta nos fenótipos metabólicos da obesidade: associações com consumo dietético, composição corporal e componentes das Homeostases energética e glicêmica
Beneficiário:Isabela Solar
Modalidade de apoio: Bolsas no Brasil - Mestrado
Processo FAPESP: 19/05450-0 - Perfil plasmático de ácidos graxos de cadeia curta e adiposidade corporal: associações com fatores ambientais nos primeiros anos de vida em mulheres participantes do NutriHS - Nutritionist Health Study
Beneficiário:Marina Gomes Barbosa
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica