Preparation of clavulanate salt using a tertiary octylamine as an intermediate

Autor(es)

Hirata, D. Battaglia ; Hortolan Luiz de Oliveira, J. H. ; Ferreira, A. G. ; Leao, K. Veloso ; Sousa, C. P. ; Barboza, M. ; Hokka, C. Osamu ; MendezVilas, A

• Tipo de documento: Artigo Científico
• Fonte: CURRENT RESEARCH TOPICS IN APPLIED MICROBIOLOGY AND MICROBIAL BIOTECHNOLOGY; v. N/A, p. 2-pg., 2009-01-01.

Resumo

This paper describes a study of the preparation of an organic ammonium salt of clavulanic acid by a precipitation reaction. The choice of clavulanic acid was based on its significance for the pharmaceutical industry and on the fact that the precipitation of this organic compound has been little Studied and is, unlike inorganic compounds, complex. The objective was to Study the influence of the initial concentration of clavulanic acid on the precipitation reaction with a tertiary octylamine. The extraction of clavulanic acid was performed at temperatures less than 20 degrees C and, preferably, near 15 degrees C in the water-immiscible organic solvents ethyl acetate. The drying step was performed with a suitable desiccant. Thus, an insoluble salt with clavulanic acid was formed. The precipitate obtained was crystalline, stable and was analyzed by H-1 NMR. (AU)

• Processo FAPESP: 05/56982-0 - Isolamento, purificacao e caracterizacao de cefamicina c e acido clavulanico de streptomyces clavuligerus.
• Beneficiário: Marlei Barboza Pasotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/55079-4 - Produção e purificação de ácido clavulânico, cefamicina C e outros metabolitos bioativos de Streptomyces
• Beneficiário: Carlos Osamu Hokka
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 04/16056-6 - Extração e purificação de ácido clavulânico por Streptomyces clavulgerus
• Beneficiário: Marlei Barboza Pasotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular