| Texto completo | |
| Autor(es): |
Castelli, E. C.
;
Mendes-Junior, C. T.
;
Deghaide, N. H. S.
;
de Albuquerque, R. S.
;
Muniz, Y. C. N.
;
Simoes, R. T.
;
Carosella, E. D.
;
Moreau, P.
;
Donadi, E. A.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Genes and Immunity; v. 11, n. 2, p. 8-pg., 2010-03-01. |
| Resumo | |
The HLA-G gene is predominantly expressed at the maternal-fetal interface. It has been associated with maternal-fetal tolerance and in the inhibition of cytotoxic T lymphocyte and natural killer cytolytic functions. At least two variations in the 3' untranslated region (UTR) of HLA-G locus are associated with HLA-G expression levels, the 14-bp deletion/insertion polymorphism and the +3142 single-nucleotide polymorphism (SNP). However, this region has not been completely characterized yet. The variability of the 3'UTR of HLA-G gene and its haplotype structure were characterized in 155 individuals from Brazil, as well as HLA-G alleles associated with each of the 3'UTR haplotype. The following eight variation sites were detected: the 14-bp polymorphism and SNPs at the positions +3003T/C, +3010C/G, +3027A/C, +3035C/T, +3142G/C, +3187A/G and +3196C/G. Similarly, 11 different 3'UTR haplotypes were identified and several HLA-G alleles presented only one 3'UTR haplotype. In addition, a high linkage disequilibrium among the variation sites was detected, especially among the 14-bp insertion and the alleles +3142G and +3187A, all previously associated with low mRNA availability, demonstrating that their effects are not independent. The detailed analyses of 3'UTR of the HLA-G locus may shed some light into mechanisms underlying the regulation of HLA-G expression. Genes and Immunity (2010) 11, 134-141; doi: 10.1038/gene.2009.74; published online 1 October 2009 (AU) | |
| Processo FAPESP: | 09/06191-7 - 5th International Conference on HLA-G |
| Beneficiário: | Celso Teixeira Mendes Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Reunião - Exterior |
| Processo FAPESP: | 07/58420-4 - Polimorfismos da região promotora e expressão de HLA-G em pacientes com histórico de carcinoma de células transicionais da bexiga urinária |
| Beneficiário: | Erick da Cruz Castelli |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |