| Texto completo | |
| Autor(es): Mostrar menos - |
Ndhlovu, Lishomwa C.
;
Leal, Fabio E.
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Hasenkrug, Aaron M.
;
Jha, Aashish R.
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Carvalho, Karina I.
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Eccles-James, Ijeoma G.
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Bruno, Fernanda R.
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Vieira, Raphaella G. S.
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York, Vanessa A.
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Chew, Glen M.
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Jones, R. Brad
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Tanaka, Yuetsu
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Neto, Walter K.
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Sanabani, Sabri S.
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Ostrowski, Mario A.
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Segurado, Aluisio C.
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Nixon, Douglas F.
;
Kallas, Esper G.
Número total de Autores: 18
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| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS Neglected Tropical Diseases; v. 5, n. 4, p. 9-pg., 2011-04-01. |
| Resumo | |
The T cell immunoglobulin mucin 3 (Tim-3) receptor is highly expressed on HIV-1-specific T cells, rendering them partially "exhausted'' and unable to contribute to the effective immune mediated control of viral replication. To elucidate novel mechanisms contributing to the HTLV-1 neurological complex and its classic neurological presentation called HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis), we investigated the expression of the Tim-3 receptor on CD8(+) T cells from a cohort of HTLV-1 seropositive asymptomatic and symptomatic patients. Patients diagnosed with HAM/TSP down-regulated Tim-3 expression on both CD8(+) and CD4(+) T cells compared to asymptomatic patients and HTLV-1 seronegative controls. HTLV-1 Tax-specific, HLA-A*02 restricted CD8(+) T cells among HAM/TSP individuals expressed markedly lower levels of Tim-3. We observed Tax expressing cells in both Tim-3(+) and Tim-3(-) fractions. Taken together, these data indicate that there is a systematic downregulation of Tim-3 levels on T cells in HTLV-1 infection, sustaining a profoundly highly active population of potentially pathogenic T cells that may allow for the development of HTLV-1 complications. (AU) | |
| Processo FAPESP: | 10/05845-0 - Resposta imune celular em doenças infecciosas e imunodeficiências primárias |
| Beneficiário: | Esper Georges Kallás |
| Modalidade de apoio: | Auxílio à Pesquisa - Pesquisador Visitante - Internacional |