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Click Chemistry: An Efficient Synthesis of Heterocycles Substituted with Steroids, Saponins, and Digitalis Analogues

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Autor(es):
Deobald, Anna M. ; Camargo, Leandro R. S. ; Alves, Diego ; Zukerman-Schpector, Julio ; Correa, Arlene G. ; Paixao, Marcio W.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: SYNTHESIS-STUTTGART; v. N/A, n. 24, p. 8-pg., 2011-12-01.
Resumo

The copper-catalyzed azide-alkyne cycloaddition (CuAAC) has been used for the construction of 1,2,3-triazole containing steroids in good to excellent yields. Combination of propargylic glycosides and steroidal azides as reaction partner allowed the synthesis of a privileged class of natural product analogues. The versatility of this protocol makes this chemistry a useful attractive approach for the synthesis of target molecules. (AU)

Processo FAPESP: 09/07281-0 - Organocatálise assimétrica: preparação de novos organocatalisadores e desenvolvimento de novas metodologias
Beneficiário:Márcio Weber Paixão
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores