| Texto completo | |
| Autor(es): |
Morais, Katia L. P.
;
Mesquita Pasqualoto, Kerly Fernanda
;
Fernandes Pacheco, Mario Thiego
;
Berra, Carolina Maria
;
Alvarez-Flores, Miryam Paola
;
Chudzinski-Tavassi, Ana Marisa
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Toxin Reviews; v. 33, n. 1-2, p. 5-pg., 2014-03-01. |
| Resumo | |
Hematophagous organisms have been described to possess specific blood coagulation inhibitors with different structures and novel mechanism of action. A factor Xa inhibitor was identified through the salivary glands transcriptome from the adult Amblyomma cajennense tick. The recombinant form was expressed in Escherichia coli and named Amblyomin-X. The recombinant protein not only inhibits factor X, but is also able to inhibit the activation of factor X by the extrinsic tenase complex. It seems to activate the apoptosis pathway through proteasome inhibition and endoplasmic reticulum-stress. It promotes regression and reduction of lung metastasis in murine melanoma tumor, and does not affect normal cells, emphasizing its selectivity of action. (AU) | |
| Processo FAPESP: | 11/05969-4 - Estudo do papel da dineína no mecanismo de ação antitumoral do Amblyomin-X em células de melanoma e adenocarcinoma de pâncreas |
| Beneficiário: | Mario Thiego Fernandes Pacheco |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 10/07958-7 - Avaliação do mecanismo de ação pró-apoptótica do amblyomin-x |
| Beneficiário: | Kátia Luciano Pereira Morais |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |