Ikaros could be a key factor in the maintenance of "B-side" of B-1 cells

Autor(es)

Oliveira, Vivian Cristina ; Moretti, Nilmar Silvo ; Augusto, Leonardo da Silva ; Schenkman, Sergio ; Mariano, Mario ; Popi, Ana Flavia

• Tipo de documento: Artigo Científico
• Fonte: Immunobiology; v. 220, n. 11, p. 8-pg., 2015-11-01.

Resumo

Ikaros, a zinc finger transcription factor, is an important regulator of the hematopoietic system. Several studies have suggested the role of Ikaros in the development, maturation, activation and differentiation of lymphocytes. To elucidate this mechanism, it is important to understand how this transcription factor works in the dichotomy of the hematopoietic system, a topic that remains uncertain. Herein, we investigated the role of Ikaros in the control of the lymphomyeloid phenotype of B-1 lymphocytes. We found that Ikaros, as well as its target genes, are expressed in B-1 cells,. Moreover, Ikaros positively regulates the expression of Flt3, Gfi and Il7r, while it down-regulates PU.1. During the induction of differentiation of B-1 cells toward phagocytes, Ikaros transcription was reduced. Taken together, these data pointed to the relevance of Ikaros in the maintenance of the promiscuous gene profile of B-1 cells. It could be suggested that Ikaros functions as a guardian of B-1 lymphoid pattern, and that its absence directs the differentiation of B-1 cells into phagocytes. (C) 2015 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 11/50256-6 - Células B-1: biologia, relações com outras células do sistema imune e participação em diferentes modelos experimentais
• Beneficiário: José Daniel Lopes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/55526-9 - Participação da via Wnt/beta-catenina na diferenciação e auto-renovação de células B-1
• Beneficiário: Ana Flavia Popi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores