Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage

Autor(es)

Silva, Priscila de Matos ; Bier, Julia ; Paiatto, Lisiery Negrini ; Albuquerque, Cassia Galdino ; Souza, Caique Lopes ; Romani Fernandes, Luis Gustavo ; da Silva Cunha Tamashiro, Wirla Maria ; Simioni, Patricia Ucelli

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2015, p. 15-pg., 2015-01-01.

Resumo

Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection. In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development. This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection. However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profile. (AU)

• Processo FAPESP: 14/16701-0 - Avaliação dos efeitos da modulação do CTLA-4 sobre o curso da resposta imune na colite experimental.
• Beneficiário: Cássia Galdino Albuquerque
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 14/08619-2 - Indução de colite experimental por TNBS e de tolerância oral a OVA em modelo experimenal murino
• Beneficiário: Caique Lopes Souza
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 14/08591-0 - Avaliação dos efeitos da tolerância oral sobre o curso da resposta imune na colite experimental
• Beneficiário: Lisiery Negrini Paiatto
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico