Overweight postmenopausal women with different plasma estradiol concentrations present with a similar pattern of energy expenditure and substrate oxidation rate before and after a fatty meal challenge

Autor(es)

Santos, Roberta de Souza ; da Silva Santos, Andressa Feijo ; Clegg, Deborah J. ; Iannetta, Odilon ; Marchini, Julio Sergio ; Miguel Suen, Vivian Marques

• Tipo de documento: Artigo Científico
• Fonte: CLINICAL NUTRITION ESPEN; v. 15, p. 7-pg., 2016-10-01.

Resumo

Menopause-related withdrawal of ovarian estrogens is associated with reduced energy metabolism and overall impairment of substrate oxidation. Estradiol's withdrawal after menopause is associated with a reduction in energy metabolism and impaired substrate oxidation, which contributes to weight gain and visceral fat accumulation. Here we aimed to investigate the association between plasma estradiol concentrations and energy expenditure (EE)/substrate oxidation in a group of overweight postmenopausal women before and after a fatty meal challenge. Women were divided into three groups according to their plasma estradiol concentrations (E2): group 1 = E2 - 39, group 2 e 40 <= E2 <= 59, and group 3 = E2 - 60 pg/mL. VO (2) and VCO2 volumes were collected following indirect calorimetry 5 h following a single lipid overload meal (1100 kcal, 72% of fat). For comparisons between groups and within the same group, a linear regression model with mixed effects was applied (P < 0.05). Forty-four women aged 55 +/- 0.7 years-old, 8 +/- 1.1 years following menopause, with a BMI of 30.5 +/- 0.5 kg/m(2), and 41.9 +/- 0.7% of body fat were enrolled the study. Plasma E2 concentrations were: group 1 e 30.4 +/- 1.9, group 2 - 46.9 +/- 1.5, and group 3 e 91.3 +/- 12.0 pg/mL (P < 0.0001). EE at baseline and in the resting state was 1320 +/- 24.3 kcal/d, and increased to 1440 +/- 27.0 kcal/d 30 min following ingestion of the fatty meal (P < 0.0001), and rose again to an average of 1475 +/- 30.3 kcal/d at the completion of experiment (P < 0.0001). Carbohydrate oxidation (Chox) was 0.155 +/- 0.01 g/min at resting, maintained as 0.133 +/- 0.00 g/min 30 min after ingestion of the fatty meal, and was 0.123 +/- 0.01 g/min at the end of the testing period. Lipid oxidation (Lipox) was 0.041 +/- 0.003 g/min at resting, increasing to 0.054 +/- 0.003 g/min at 30 min (P 1/4 0.01), and reaching 0.063 +/- 0.003 g/min at the end of the experiment (P < 0.0001). Therewas no difference between groups for EE, Chox or Lipox. Our data suggest that EE and substrate oxidation weremodulated following a lipid-meal challenge equally in all groups and this did not differ with plasma E2 concentrations. (c) 2016 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/56456-4 - Efeito de uma sobrecarga lipidica sobre o metabolismo energetico de pacientes climatericas com e sem a utilizacao de terapia de reposicao hormonal
• Beneficiário: Roberta de Souza Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/51564-3 - Efeito de uma sobrecarga lipídica sobre o metabolismo energético de mulheres climatéricas com e sem utilização de terapia hormonal
• Beneficiário: Roberta de Souza Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto