Association of Heme Oxygenase 1 with Lung Protection in Malaria-Associated ALI/ARDS

Autor(es)

Pereira, Marcelo L. M. ; Ortolan, Luana S. ; Sercundes, Michelle K. ; Debone, Daniela ; Murillo, Oscar ; Lima, Flavia A. ; Marinho, Claudio R. F. ; Epiphanio, Sabrina

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2016, p. 12-pg., 2016-01-01.

Resumo

Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset ofMA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans. (AU)

• Processo FAPESP: 12/10081-5 - O papel da heme oxigenase 1 na injúria pulmonar aguda associada à malária
• Beneficiário: Marcelo Luís Monteiro Pereira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 09/53256-7 - Identificação e caracterização da síndrome respiratória aguda murina associada à malária severa: estudo da interação parasito-hospedeiro
• Beneficiário: Sabrina Epiphanio
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/09964-5 - O papel dos inflamassomas na patogênese da malária associada à gravidez: efeitos e mecanismos
• Beneficiário: Cláudio Romero Farias Marinho
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/20451-0 - O papel das células endoteliais na imunopatogênese da LPA/SDRA murina associado à malária: efeitos e mecanismos
• Beneficiário: Sabrina Epiphanio
• Modalidade de apoio: Auxílio à Pesquisa - Regular