| Texto completo | |
| Autor(es): |
Pereira, Marcelo L. M.
;
Ortolan, Luana S.
;
Sercundes, Michelle K.
;
Debone, Daniela
;
Murillo, Oscar
;
Lima, Flavia A.
;
Marinho, Claudio R. F.
;
Epiphanio, Sabrina
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Mediators of Inflammation; v. 2016, p. 12-pg., 2016-01-01. |
| Resumo | |
Malaria is a serious disease, caused by the parasite of the genus Plasmodium, which was responsible for 440,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications in severe malaria. The murine model DBA/2 reproduces the clinical signs of ALI/ARDS in humans, when infected with Plasmodium berghei ANKA. High levels of HO-1 were reported in cases of severe malaria. Our data indicated that the HO-1 mRNA and protein expression are increased in mice that develop malaria-associated ALI/ARDS (MA-ALI/ARDS). Additionally, the hemin, a HO-1 inducing drug, prevented mice from developing MA-ALI/ARDS when administered prior to the development of MA-ALI/ARDS in this model. Also, hemin treatment showed an amelioration of respiratory parameters in mice, high VEGF levels in the sera, and a decrease in vascular permeability in the lung, which are signs of ALI/ARDS. Therefore, the induction of HO-1 before the development of MA-ALI/ARDS could be protective. However, the increased expression of HO-1 on the onset ofMA-ALI/ARDS development may represent an effort to revert the phenotype of this syndrome by the host. We therefore confirm that HO-1 inducing drugs could be used for prevention of MA-ALI/ARDS in humans. (AU) | |
| Processo FAPESP: | 12/10081-5 - O papel da heme oxigenase 1 na injúria pulmonar aguda associada à malária |
| Beneficiário: | Marcelo Luís Monteiro Pereira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 09/53256-7 - Identificação e caracterização da síndrome respiratória aguda murina associada à malária severa: estudo da interação parasito-hospedeiro |
| Beneficiário: | Sabrina Epiphanio |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 14/09964-5 - O papel dos inflamassomas na patogênese da malária associada à gravidez: efeitos e mecanismos |
| Beneficiário: | Cláudio Romero Farias Marinho |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/20451-0 - O papel das células endoteliais na imunopatogênese da LPA/SDRA murina associado à malária: efeitos e mecanismos |
| Beneficiário: | Sabrina Epiphanio |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |