Genetic Polymorphisms of IL17 and Chagas Disease in the South and Southeast of Brazil

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Reis, Pmela Guimaraes ; Ayo, Christiane Maria ; de Mattos, Luiz Carlos ; Brandao de Mattos, Cinara de Cssia ; Sakita, Karina Mayumi ; de Moraes, Amarilis Giaretta ; Muller, Larissa Pires ; Aquino, Julimary Suematsu ; Macedo, Luciana Conci ; Mazini, Priscila Saamara ; Sell, Ana Maria ; de Oliveira Marques, Divina Seila ; Bestetti, Reinaldo Bulgarelli ; Laguila Visentainer, Jeane Eliete

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2017, p. 7-pg., 2017-01-01.

Resumo

Theaimof this study was to investigate possible associations between genetic polymorphisms of IL17A G197A (rs2275913) and IL17F T7488C (rs763780) with Chagas Disease (CD) and/or the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas cardiomyopathy (CCC). The study with 260 patients and 150 controls was conducted in the South and Southeast regions of Brazil. Thegenotyping was performed by PCR-RFLP. The A allele and A/A genotype of IL17A were significantly increased in patients and their subgroups patients with CCC; patients with CCCand LVSD; and patients with CCCand severe LVSD) when compared to the control group. The analysis according to the gender showed that the A/A genotype of IL17A was more frequent in female with LVSD and mild to moderate LVSD and also in male patients with LVSD. The frequency of IL17F T/C genotype was male patients with CCC and severe LVSD and in female with mild to moderate LVSD. The results suggest the possible involvement of the polymorphisms of IL17A and IL17F in the susceptibility to chronic Chagas disease and in development and progression of cardiomyopathy. (AU)

• Processo FAPESP: 13/06580-9 - Genes KIR, seus ligantes HLA e polimorfismo do gene MICA na toxoplasmose ocular e na forma digestiva da doença de Chagas
• Beneficiário: Christiane Maria Ayo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/08075-4 - Marcadores imunogenéticos relacionados à doença de Chagas
• Beneficiário: Luiz Carlos de Mattos
• Modalidade de apoio: Auxílio à Pesquisa - Regular