Light-Emitting Diode treatment ameliorates allergic lung inflammation in experimental model of asthma induced by ovalbumin

Autor(es)

Cardoso Siqueira, Vanessa Perosino ; Silveira Evangelista, Marina Izadora ; dos Santos, Alana ; Marcos, Rodrigo Labat ; Ligeiro-de-Oliveira, Ana Paula ; Pavani, Christiane ; Damazo, Amilcar Sabino ; Lino-dos-Santos-Franco, Adriana

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biophotonics; v. 10, n. 12, p. 11-pg., 2017-12-01.

Resumo

Since asthma is a multifactorial disease where treatment sometimes is not effective, new therapies that improve the respiratory discomfort of patients are of great importance. Phototherapy as Light-emitting diode (LED) has emerged as a treatment that presents good results for diseases that are characterized by inflammation. Thus, our objective was to investigate the effects of LED on lung inflammation, by an evaluation of lung cell infiltration, mucus secretion, oedema, and the production of cytokines. Male Balb/c mice were or not sensitized and challenged with ovalbumin (OVA) and treated or not with LED therapy (1 h and 4 h after each OVA challenge). Twenty-four hours after the last OVA challenge, analyzes were performed. Our results showed that LED treatment in asthmatic mice reduced the lung cell infiltration, the mucus production, the oedema, and the tracheal's contractile response. It also increased the IL-10 and the IFN-gamma levels. The effects of LED treatment on lung inflammation may be modulated by IL-10, IFN-gamma, and by mast cells. This study may provide important information about the effects of LED, and in addition, it may open the possibility of a new approach for the treatment of asthma. (AU)

• Processo FAPESP: 15/08041-3 - Efeito da LED terapia sobre parâmetros inflamatórios em modelo experimental de asma
• Beneficiário: Marina Izadora Silveira Evangelista
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/00830-9 - Efeitos da exposição à poluição ambiental/ocupacional sobre a fibrose pulmonar idiopática
• Beneficiário: Adriana Lino dos Santos Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular