Regulation of tRNA biogenesis in plants and its link to plant growth and response to pathogens

Autor(es)

Soprano, Adriana Santos ; Costa Smetana, Juliana Helena ; Benedetti, Celso Eduardo

• Tipo de documento: Artigo Científico
• Fonte: BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS; v. 1861, n. 4, p. 10-pg., 2018-04-01.

Resumo

The field of tRNA biology, encompassing the functional and structural complexity of tRNAs, has fascinated scientists over the years and is continuously growing. Besides their fundamental role in protein translation, new evidence indicates that tRNA-derived molecules also regulate gene expression and protein synthesis in all domains of life. This review highlights some of the recent findings linking tRNA transcription and modification with plant cell growth and response to pathogens. In fact, mutations in proteins directly involved in tRNA synthesis and modification most often lead to pleiotropic effects on plant growth and immunity. As plants need to optimize and balance their energy and nutrient resources towards growth and defense, regulatory pathways that play a central role in integrating tRNA transcription and protein translation with cell growth control and organ development, such as the auxin-TOR signaling pathway, also influence the plant immune response against pathogens. As a consequence, distinct pathogens employ an array of effector molecules including tRNA fragments to target such regulatory pathways to exploit the plant's translational capacity, gain access to nutrients and evade defenses. An example includes the RNA polymerase III repressor MAF1, a conserved component of the TOR signaling pathway that controls ribosome biogenesis and tRNA synthesis required for plant growth and which is targeted by a pathogen effector molecule to promote disease. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena. (AU)

• Processo FAPESP: 14/12445-0 - Caracterização estrutural do complexo Ragulator, mediador da sinalização por aminoácidos na via da mTORC1
• Beneficiário: Juliana Helena Costa Smetana
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/20468-1 - Modelos biológicos de interação planta-patógeno para o entendimento de mecanismos de patogenicidade e adaptação de fitobactérias, respostas de defesa e desenvolvimento de doença em citros
• Beneficiário: Celso Eduardo Benedetti
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/06736-6 - Análise funcional da MAF1 de citros, um regulador negativo da RNA pol III envolvido com o desenvolvimento do cancro cítrico
• Beneficiário: Adriana Santos Soprano
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado