Neonatal Immunity to Bordetella pertussis Infection and Current Prevention Strategies

Autor(es)

Argondizo-Correia, Carolina ; Sousa Rodrigues, Ana Kelly ; de Brito, Cyro Alves

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2019, p. 10-pg., 2019-01-01.

Resumo

Bordetella pertussis is the bacterial agent of whooping cough, an infectious disease that is reemerging despite high vaccine coverage. Newborn children are the most affected, not only because they are too young to be vaccinated but also due to qualitative and quantitative differences in their immune system, which makes them more susceptible to infection and severe manifestations, leading to a higher mortality rate comparing to other groups. Until recently, prevention consisted of vaccinating children in the first year of life and the herd vaccination of people directly in touch with them, but the increase in cases demands more effective strategies that can overcome the developing immune response in early life and induce protection while children are most vulnerable. (AU)

• Processo FAPESP: 15/19726-7 - Influência da vacinação com DTPa em gestantes no perfil da resposta imunológica contra a Bordetella pertussis na criança
• Beneficiário: Carolina Argondizo Correia
• Modalidade de apoio: Bolsas no Brasil - Mestrado