Synthesis of pseudoboehmite-graphene oxide for drug delivery system

Autor(es)

Munhoz Jr, Antonio Hortencio ; Romero Filho, Marcos ; Kleist, Henrique de Arruda ; Moreno, Guilherme Dias ; de Oliveira, Mariana Oliva ; Peres, Renato Meneghetti ; Rossi, Maura Vincenza ; de Miranda, Leila Figueiredo ; Ribeiro, Roberto Rodrigues ; Cardoso Sarmento, Bruno Filipe Carmelino

• Tipo de documento: Artigo Científico
• Fonte: MATERIALS TODAY-PROCEEDINGS; v. 14, p. 8-pg., 2019-01-01.

Resumo

Pseudoboehmite is a hydrated aluminium compound produced by sol-gel process and used in drug delivery systems. The graphene oxide is a material that allows for many possibilities application as modify agent in a ceramic structure. The global prevalence and incidence of herpes simplex virus infections (HSV-1 and HSV-2) have risen worldwide. A big problem is that most persons with genital HSV infection have not received a diagnosis. Other concerning situation is that the herpes infected patients are more susceptible to HIV infections. It is also observed that in women the HSV infection are more common than in men. Acyclovir is an efficient drug for the treatment of herpes viruses. However, the oral bioavailability of acyclovir is limited due to varying and incomplete absorption. In this work, pseudoboehmite was produced with incorporation of graphene oxide in the gel. The pseudoboehmite-graphene oxide was used in in vitro drug delivery system for acyclovir. (C) 2019 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 17/22396-4 - "síntese de nanoparticulas de pseudoboemita"
• Beneficiário: Antonio Hortencio Munhoz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/19157-9 - Síntese de pseudoboemitas modificadas visando à obtenção de nanosistemas para liberação controlada de fármacos
• Beneficiário: Antonio Hortencio Munhoz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular