Human platelet antigen polymorphisms and the risk of chronic Chagas disease cardiomyopathy

Autor(es)

do Carmo Correa, Deborah Elzita ; Ayo, Christiane Maria ; Laguila Visentainer, Jeane Eliete ; Ambrosio-Albuquerque, Eliane Papa ; Reis, Pamela Guimaraes ; Brandao de Mattos, Cinara Cassia ; Bestetti, Reinaldo Bulgarelli ; de Mattos, Luiz Carlos ; Sell, Ana Maria

• Tipo de documento: Artigo Científico
• Fonte: PLATELETS; v. 31, n. 2, p. 4-pg., 2019-09-22.

Resumo

Human platelet antigen (HPA) polymorphisms are considered to be a risk factor for cardiac and vascular diseases, but the role of HPA in chronic Chagas disease cardiomyopathy (CCC) is not available. Therefore, the aim of this study was to investigate the association of HPA polymorphisms, HPA-1, HPA-2, HPA-3, HPA-5 and HPA-15, in the severity of left ventricular systolic dysfunction (LVSD) in CCC patients. For this, 229 CCC patients were separated into three groups: without LVSD, mild/moderate LVSD and severe LVSD. PCR-SSP was performed for HPA genotyping and the risk was assessed using SNPStats software. HPA-1 allele and genotype frequencies were lower in mild/moderate LVSD patients compared to other groups, without statistical significance. After stratified analyzes, the HPA-3a/3b genotype frequency was lower in women with severe LVSD compared to those without LVSD (OR:0.29; 95% CI: 0.10-0.84). In conclusion, HPA-3 variant could be a protection factor for CCC in the female patients. (AU)

• Processo FAPESP: 13/06580-9 - Genes KIR, seus ligantes HLA e polimorfismo do gene MICA na toxoplasmose ocular e na forma digestiva da doença de Chagas
• Beneficiário: Christiane Maria Ayo
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 11/08075-4 - Marcadores imunogenéticos relacionados à doença de Chagas
• Beneficiário: Luiz Carlos de Mattos
• Modalidade de apoio: Auxílio à Pesquisa - Regular