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Calcium signalling: A common target in neurological disorders and neurogenesis

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Autor(es):
Glaser, Talita ; Arnaud Sampaio, Vanessa Fernandes ; Lameu, Claudiana ; Ulrich, Henning
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY; v. 95, p. 9-pg., 2019-11-01.
Resumo

Calcium is an ubiquitous second messenger used by any living cell. The fine-tuning of intracellular free calcium concentration ([Ca2+](i)) homeostasis and signalling pathways is crucial for the maintenance of the healthy organism. Many alterations in the homeostasis can be compensated by robust mechanisms; however, cells that already present some debility in those mechanisms, or that are over stimulated cannot compensate the stress and die. Many neurological diseases show [Ca2+] disbalance as trigger of apoptotic response resulting in massive neuronal loss and the neurodegeneration. In this review, we focus on presenting similarities and differences of neurological disorders like Huntington's, Parkinson's, Alzheimer's disease and schizophrenia and the current clinical trial status. Moreover, we describe the importance of Ca2+ signalling in neurogenesis, showing that interference of this signalling could go along with stem cell therapy in the central nervous system. (AU)

Processo FAPESP: 15/19128-2 - Mecanismos de metástase de tumores infantis para a medula óssea
Beneficiário:Claudiana Lameu
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 15/13345-1 - Doença de Huntington: envolvimento de Huntingtin no controle do comprometimento celular
Beneficiário:Talita Glaser
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 12/50880-4 - Células-tronco: dos papéis de receptores de cininas e purinas às aplicações terapêuticas
Beneficiário:Alexander Henning Ulrich
Modalidade de apoio: Auxílio à Pesquisa - Temático