Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori

Autor(es)

dos Santos, Monica Pezenatto ; Pereira, Jessica Nunes ; De Labio, Roger Willian ; Carneiro, Lilian Carla ; Pontes, Jaqueline Correia ; Barbosa, Monica Santiago ; Cardoso Smith, Marilia De Arruda ; Marques Payao, Spencer Luiz ; Rasmussen, Lucas Trevizani

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF GASTROINTESTINAL CANCER; v. 52, n. 2, p. 6-pg., 2020-06-06.

Resumo

Purpose The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. pylori. Methods Patients were divided in groups according to histopathological analysis (control, gastritis, and cancer groups). Polymerase chain reaction was performed to detect H. pylori and real-time quantitative PCR to determine miR-125a-5p expression. Results H. pylori was detected in 44% of the patients, with prevalence in the gastritis and cancer groups. A statistically significant decrease of miR-125a-5p expression was found in the control positive (p = 0.0183*), gastritis positive (p = 0.0380*), and cancer positive (p = 0.0288*) groups when compared with the control negative group. Conclusion We suggest that decreased expression of the miRNA-125a-5p associated with the presence of the H. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer. (AU)

• Processo FAPESP: 18/02008-2 - Análise da expressão dos micros RNAs miR-let7a, miR-125a, miR-155 e dos genes da interleucina 6 e seu receptor-alpha em pacientes com doenças gástricas e cultura celular: uma possível associação com o H. pylori
• Beneficiário: Monica Pezenatto dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/08481-1 - Análise da Interação Gênica e Proteica entre Componentes das Vias Inflamatória, da Apoptose e MicroRNAs em Doença Dispéptica e Câncer Gástrico
• Beneficiário: Lucas Trevizani Rasmussen
• Modalidade de apoio: Auxílio à Pesquisa - Regular