| Texto completo | |
| Autor(es): Mostrar menos - |
Ruiz, Francieli S.
;
Beijamini, Felipe
;
Beale, Andrew D.
;
Goncalves, Bruno da Silva B.
;
Vartanian, Daniel
;
Taporoski, Tamara P.
;
Middleton, Benita
;
Krieger, Jose E.
;
Vallada, Homero
;
Arendt, Josephine
;
Pereira, Alexandre C.
;
Knutson, Kristen L.
;
Pedrazzoli, Mario
;
von Schantz, Malcolm
Número total de Autores: 14
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Pineal Research; v. 69, n. 3, p. 12-pg., 2020-07-19. |
| Resumo | |
Studying communities at different stages of urbanisation and industrialisation can teach us how timing and intensity of light affect the circadian clock under real-life conditions. We have previously described a strong tendency towards morningness in the Baependi Heart Study, located in a small rural town in Brazil. Here, we tested the hypothesis that this morningness tendency is associated with early circadian phase based on objective measurements (as determined by dim light melatonin onset, DLMO, and activity) and light exposure. We also analysed how well the previously collected chronotype questionnaire data were able to predict these DLMO values. The average DLMO observed in 73 participants (40 female) was 20:03 +/- 01:21, SD, with an earlier average onset in men (19:38 +/- 01:16) than in women (20:24 +/- 01:21;P <= .01). However, men presented larger phase angle between DLMO and sleep onset time as measured by actigraphy (4.11 hours vs 3.16 hours;P <= .01). Correlational analysis indicated associations between light exposure, activity rhythms and DLMO, such that early DLMO was observed in participants with higher exposure to light, higher activity and earlier light exposure. The strongest significant predictor of DLMO was morningness-eveningness questionnaire (MEQ) (beta=-0.35,P <= .05), followed by age (beta = -0.47,P <= .01). Sex, light exposure and variables derived from the Munich chronotype questionnaire were not significant predictors. Our observations demonstrate that both early sleep patterns and earlier circadian phase have been retained in this small rural town in spite of availability of electrification, in contrast to metropolitan postindustrial areas. (AU) | |
| Processo FAPESP: | 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira. |
| Beneficiário: | Andréa Roseli Vançan Russo Horimoto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther |
| Beneficiário: | José Eduardo Krieger |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |