Effect of incoherent LED radiation on third-degree burning wounds in rats

Autor(es)

Fiorio, Franciane B. ^[1] ; Silveira, Jr., Landulfo ^[2] ; Munin, Gberto ^[2] ; de Lima, Carlos Jose ^[2] ; Fernandes, Kristianne P. S. ^[3] ; Mesqui Ta-Ferrari, Raquel Agnelli ^[3] ; de Carvalho, Paulo de Tarso C. ^[3] ; Brandao Lopes-Martins, Rodrigo Alvaro ^{[4, 3]} ; Aimbire, Flavio ^[5] ; de Carvalho, Regiane Albertini ^[3]

Afiliação do(s) autor(es)

^[1] Chapeco Univ UNOCHAPEC, Hlth Sci Ctr, Chapeco, SC - Brazil

^[2] Camilo Castelo Branco Univ UNICASTELO, Inst Biomed Engineer, Sao Jose Dos Campos, SP - Brazil

^[3] Nove Julho Univ UNINOVE, Dept Rehabil Sci, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pharmacol, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Sci & Technol, Unifesp, BR-12231280 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cosmetic and Laser Therapy; v. 13, n. 6, p. 315-322, DEC 2011.
• Citações Web of Science: 9

Resumo

The main physiological characteristics in a burn process are the increase of the capillary permeability and the occurrence of edema and exudation. Light-emitting diode (LED) has been proposed as treatment of burning. This study investigated the effects of LED on the repair process of rat skin submitted to a third-degree burning. The lesions were produced on the dorsal surface of male Wistar rats. Animals were divided into 4 groups (n = 6) as follows: L1 and L2 groups as LED-treated burned rats, and received LED therapy along 7 and 15 days with 48 hours intervals, respectively; C1 and C2 groups as control, non-treated burned rats. A red LED (640 nm, 30 mW) operating with a fluence of 4 J/cm(2) was used. The wound area was measured daily after irradiation. Animals were euthanized at the 8th and 16th days after burning, and the wound fragment was submitted to histology. The inflammatory cells as well as the damaged area at the 8th day after burns were significantly lower for the LED-treated group when compared to control. Furthermore, the LED phototherapy effect on cellular migration was even more pronounced at the 16th day. Our results indicated that the treatment with a LED system was clearly effective in reducing the number of inflammatory cells and improving the healing process in an experimental model of third-degree burnings. (AU)

• Processo FAPESP: 07/02596-7 - Analise do mecanismo de acao da terapia laser de baixa potencia em modelo experimental de inflamacao cronica.
• Beneficiário: Regiane Albertini
• Modalidade de apoio: Auxílio à Pesquisa - Regular