COMT polymorphism and the risk of endometriosis-related infertility

Autor(es)

Christofolini, Denise Maria ^[1] ; Teles, Juliana Souto ^[1] ; Vilarino, Fabia Lima ^[1] ; Andre, Gustavo Mendonca ^[1] ; Bianco, Bianca ^[1] ; Barbosa, Caio Parente ^[1]

Afiliação do(s) autor(es)

^[1] ABC, Fac Med, Dept Gynecol & Obstet, BR-09060650 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Gynecological Endocrinology; v. 27, n. 12, p. 1099-1102, DEC 2011.
• Citações Web of Science: 7

Resumo

Estrogens are important factors in the development of endometriosis, and can induce cell proliferation and stimulate cell division. COMT constitutes a crucial element in estrogen metabolism and has been suggested to be involved in the development of endometriosis. This study had the objective of to determine whether the presence of COMT val/met polymorphism (rs4680) increases the risk to endometriosis in infertile patients. A case-control study that included 198 infertile women with endometriosis, 71 infertile women without endometriosis, and 168 fertile women as control group of the Faculdade de Medicina do ABC. COMT (val/met) genotypes were identified by real time PCR (genotyping TaqMan assay) and the results were analyzed statistically by chi(2) test. The data showed no statistical difference in the distribution of COMT genotypes neither between infertile patients with endometriosis and control group (p = 0.567), regardless disease degree, nor between infertile patients without endometriosis and control group (p = 0.460). In conclusion, the COMT val/met polymorphism is not associated to endometriosis-related infertility in the Brazilian population evaluated. However, more studies in larger populations are necessary to confirm these results. (AU)

• Processo FAPESP: 09/01960-2 - Estudo de polimorfismo do gene ptpn22 em mulheres portadoras de endometriose
• Beneficiário: Juliana Souto Teles
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica