From Sperm Motility to Sperm-Borne microRNA Signatures: New Approaches to Predict Male Fertility Potential

Autor(es)

Alves, Maira Bianchi Rodrigues ; Celeghini, Eneiva Carla Carvalho ; Belleannee, Clemence

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 8, p. 16-pg., 2020-08-21.

Resumo

In addition to the paternal genome, spermatozoa carry several intrinsic factors, including organelles (e.g., centrioles and mitochondria) and molecules (e.g., proteins and RNAs), which are involved in important steps of reproductive biology such as spermatogenesis, sperm maturation, oocyte fertilization and embryo development. These factors constitute potential biomarkers of "viable sperm" and male fertility status and may become major assets for diagnosing instances of idiopathic male infertility in both humans and livestock animals. A better understanding of the mechanism of action of these sperm intrinsic factors in the regulation of reproductive and developmental processes still presents a major challenge that must be addressed. This review assembles the main data regarding morpho-functional and intrinsic sperm features that are associated with male infertility, with a particular focus on microRNA (miRNA) molecules. (AU)

• Processo FAPESP: 15/09154-6 - Perfil de microRNAs presentes no sêmen e embriões bovinos e sua relação com a fertilidade
• Beneficiário: Maíra Bianchi Rodrigues Alves
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/05395-1 - Perfil de microRNAs presentes no sêmen e embriões bovinos e sua relação com a fertilidade
• Beneficiário: Eneiva Carla Carvalho Celeghini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/23243-4 - Perfil de microRNAs de espermatozóides humanos e murinos coletados de diferentes partes do sistema reprodutivo
• Beneficiário: Maíra Bianchi Rodrigues Alves
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado