Tc-99m-sestamibi SPECT/CT and(18)F-FDG-PET/CT have similar performance but different imaging patterns in newly diagnosed multiple myeloma

Autor(es):Mostrar menos -

Mosci, Camila ; Pericole, Fernando V. ; Oliveira, Gislaine B. ; Delamain, Marcia T. ; Takahashi, Maria E. S. ; Carvalheira, Jose Barreto C. ; Etchebehere, Elba C. S. C. ; Santos, Allan O. ; Miranda, Eliana C. M. ; Lima, Mariana C. L. ; Amorim, Barbara J. ; de Souza, Carmino A. ; Lorand-Metze, Irene ; Ramos, Celso D.

• Tipo de documento: Artigo Científico
• Fonte: NUCLEAR MEDICINE COMMUNICATIONS; v. 41, n. 10, p. 8-pg., 2020-10-01.

Resumo

Purpose F-18-fluorodeoxiglucose (F-18-FDG)-PET/CT has been widely used to evaluate multiple myeloma.Tc-99m-sestamibi (MIBI) scintigraphy has also been proposed for assessing multiple myeloma, but its use with state-of-the-art single-photon emission computed tomography/computed tomography (SPECT/CT) technology has not been fully evaluated.This study aimed to compare these two imaging modalities in multiple myeloma staging. Materials and methods Sixty-two patients with recently diagnosed multiple myeloma were submitted to whole-body(18)F-FDG-PET/CT and whole-body MIBI scans plus SPECT/CT of the chest and abdomen/pelvis. Number of focal lesions, contiguous soft tissue involvement (CSTI), extramedullary lesions (EMLs) and diffuse bone marrow (BM) involvement were recorded. Results PET/CT was positive in 59 patients (95%) and MIBI SPECT/CT in 58 (93%) (P = 0.69). MIBI detected more diffuse bone marrow involvement than PET/CT (respectively 78 vs. 58% of the patients), while PET/CT demonstrated more focal lesions than MIBI SPECT/CT (81 vs. 54% of the patients) (P = 0.002). PET/CT detected EMLs in four subjects and MIBI in one subject. CSTI was found in 28 (45%) and 23 (37%) patients on PET/CT and MIBI images, respectively (P = 0.36). Three patients with lytic lesions and no FDG uptake were MIBI positive, and two subjects with lytic lesions without MIBI uptake were FDG positive. Conclusion MIBI SPECT/CT performs similarly to(18)F-FDG-PET/CT in identifying sites of active disease in multiple myeloma staging. MIBI is more efficient than FDG for detecting the diffuse involvement of bone marrow but less efficient for detecting focal lesions. Some patients presented a 'mismatch' pattern of FDG/MIBI uptake. (AU)

• Processo FAPESP: 18/14132-0 - EANM'18 - Congresso Anual da Associação Europeia de Medicina Nuclear
• Beneficiário: Celso Darío Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Reunião - Exterior
• Processo FAPESP: 18/00654-4 - ESTUDO PILOTO DE COMPARAÇÃO ENTRE NEOVASCULARIZAÇÃO E HIPERMETABOLISMO CELULAR NO MIELOMA MÚLTIPLO UTILIZANDO IMAGENS DE PET/CT PSMA-68Ga E PET/CT FDG-18F
• Beneficiário: Celso Darío Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/54065-0 - EMU: aquisição de PET/CT para quantificação da atividade metabólica de tecidos vivos
• Beneficiário: Carmino Antonio de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários