The role of osteopontin in oral cancer: A brief review with emphasis on clinical applications

Autor(es)

dos Santos, Erison Santana ; Ramos, Joab Cabral ; Oliveira Correa Roza, Ana Luiza ; Linhares Almeida Mariz, Bruno Augusto ; Paes Leme, Adriana Franco

• Tipo de documento: Artigo Científico
• Fonte: ORAL DISEASES; v. 28, n. 2, p. 10-pg., 2020-12-03.

Resumo

Osteopontin (OPN) is a calcium-binding glycol-phosphoprotein present in many physiologic and pathological processes. This protein can control bone cell adhesion, osteoclastic activity, and bone matrix mineralization. However, its participation in pathological processes such as atherosclerosis, sarcoidosis, tuberculosis, and cancer have been described. Some studies have shown that OPN may participate in the development and progression of oral cancer. Although the role of OPN in oral cancer is not fully understood, some studies have suggested that this protein may induce malignant phenotype of cells by activation of PI3K/AKT/mTOR pathway, which favors cell proliferation, invasion, metastasis, angiogenesis, and failure of treatment. This review discusses the possible mechanism of involvement of OPN in oral cancer and its potential clinical application in diagnosis and prognosis. (AU)

• Processo FAPESP: 18/19922-9 - Análise proteômica dos fluidos lacrimais em pacientes com lesões orais potencialmente malignas e câncer de boca
• Beneficiário: Erison Santana dos Santos
• Modalidade de apoio: Bolsas no Brasil - Mestrado