Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

Autor(es)

de Araujo, William R. ^[1] ; Paixao, Thiago R. L. C. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electroanalysis; v. 23, n. 11, p. 2549-2554, NOV 2011.
• Citações Web of Science: 3

Resumo

A simple analytical method for ranitidine quantification was developed based on the electrocatalytic oxidation of ranitidine on a glassy carbon electrode modified by electrochemical deposition of ruthenium oxide hexacyanoferrate. Under optimal experimental conditions, the peak current response increases linearly with a ranitidine concentration over the range of 1.25-7.50 mu mol L(-1). The detection limit of the method was estimated to be 25 mu mol L(-1). The proposed method improves the analytical parameters obtained by other electroanalytical methods for the quantification of this drug, and it was employed for quantification of ranitidine in 3 commercial samples, the results being in agreement with those obtained by the manufactures. (AU)

• Processo FAPESP: 09/07859-1 - Desenvolvimento de línguas eletrônicas voltamétricas visando à caracterização e identificação de processos de adulteração e falsificação em biocombustíveis
• Beneficiário: Thiago Regis Longo Cesar da Paixão
• Modalidade de apoio: Auxílio à Pesquisa - Regular