Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

Author(s)

de Araujo, William R. ^[1] ; Paixao, Thiago R. L. C. ^{[1, 2]}

Affiliation

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP - Brazil

^[2] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo - Brazil

• Document type: Journal article
• Source: Electroanalysis; v. 23, n. 11, p. 2549-2554, NOV 2011.
• Web of Science Citations: 3

Abstract

A simple analytical method for ranitidine quantification was developed based on the electrocatalytic oxidation of ranitidine on a glassy carbon electrode modified by electrochemical deposition of ruthenium oxide hexacyanoferrate. Under optimal experimental conditions, the peak current response increases linearly with a ranitidine concentration over the range of 1.25-7.50 mu mol L(-1). The detection limit of the method was estimated to be 25 mu mol L(-1). The proposed method improves the analytical parameters obtained by other electroanalytical methods for the quantification of this drug, and it was employed for quantification of ranitidine in 3 commercial samples, the results being in agreement with those obtained by the manufactures. (AU)

• FAPESP's process: 09/07859-1 - Development of voltammetric electronic tongues towards the characterization and identification of adulteration and falsification processes of biofuels
• Grantee: Thiago Regis Longo Cesar da Paixão
• Support Opportunities: Regular Research Grants