Mineral intake independent from gastric irritation or pica by cell-dehydrated rats

Autor(es)

Constancio, Juliana ^[1] ; Pereira-Derderian, Daniela T. B. ^[1] ; Menani, Jose V. ^[1] ; De Luca, Jr., Laurival A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Physiology & Behavior; v. 104, n. 5, p. 659-665, OCT 24 2011.
• Citações Web of Science: 6

Resumo

Gavage of 2 M NaCl (IG 2 M NaCl), a procedure to induce cell-dehydration-and water and 015 M NaCl intake in a two-bottle choice test-is also a potential gastric irritant. In this study, we assessed whether mineral intake induced by IG 2 M NaCl is associated with gastric irritation or production of pica in the rat. We first determined the amount of mineral solution (0.15 M NaCl, 0.15 M NaHCO(3), 0.01 M KCl and 0.05 mM CaCl(2)) and water ingested in response to IG 2 M NaCl in a five-bottle test. Then, we used mineral solutions (0.01 M KCl and 0.15 M NaHCO(3)), whose intakes were significantly increased compared to controls, and water in three-bottle tests to test the gastric irritation hypothesis. The IG 2 M NaCl induced KCl and NaHCO(3) intake that was not inhibited by gavage with gastric protectors Al(OH)(3) or NaHCO(3). IG 2 M NaCl or gavage of 0.6 N acetic acid induced mild irritation, hyperemia, of the glandular part of the stomach. A gavage of 50% ethanol induced strong irritation seen as pinpoint ulcerations. Neither ethanol nor acetic acid induced any fluid intake. Neither IG 2 M NaCl nor acetic acid induced kaolin intake, a marker of pica in laboratory rats. Ethanol did induce kaolin intake. These results suggest that IG 2 M NaCl induced a mineral fluid intake not selective for sodium and independent from gastric irritation or pica. (C) 2011 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 06/58829-7 - Controle da ingestao de agua e de sal - efeitos da gavagem de naci hipertonico.
• Beneficiário: Juliana Constancio
• Modalidade de apoio: Bolsas no Brasil - Mestrado