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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mineral intake independent from gastric irritation or pica by cell-dehydrated rats

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Author(s):
Constancio, Juliana [1] ; Pereira-Derderian, Daniela T. B. [1] ; Menani, Jose V. [1] ; De Luca, Jr., Laurival A. [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Physiology & Behavior; v. 104, n. 5, p. 659-665, OCT 24 2011.
Web of Science Citations: 6
Abstract

Gavage of 2 M NaCl (IG 2 M NaCl), a procedure to induce cell-dehydration-and water and 015 M NaCl intake in a two-bottle choice test-is also a potential gastric irritant. In this study, we assessed whether mineral intake induced by IG 2 M NaCl is associated with gastric irritation or production of pica in the rat. We first determined the amount of mineral solution (0.15 M NaCl, 0.15 M NaHCO(3), 0.01 M KCl and 0.05 mM CaCl(2)) and water ingested in response to IG 2 M NaCl in a five-bottle test. Then, we used mineral solutions (0.01 M KCl and 0.15 M NaHCO(3)), whose intakes were significantly increased compared to controls, and water in three-bottle tests to test the gastric irritation hypothesis. The IG 2 M NaCl induced KCl and NaHCO(3) intake that was not inhibited by gavage with gastric protectors Al(OH)(3) or NaHCO(3). IG 2 M NaCl or gavage of 0.6 N acetic acid induced mild irritation, hyperemia, of the glandular part of the stomach. A gavage of 50% ethanol induced strong irritation seen as pinpoint ulcerations. Neither ethanol nor acetic acid induced any fluid intake. Neither IG 2 M NaCl nor acetic acid induced kaolin intake, a marker of pica in laboratory rats. Ethanol did induce kaolin intake. These results suggest that IG 2 M NaCl induced a mineral fluid intake not selective for sodium and independent from gastric irritation or pica. (C) 2011 Elsevier Inc. All rights reserved. (AU)