| Texto completo | |
| Autor(es): |
de Farias, Natalia Oliveira
;
Rodrigues, Amanda Rocha
;
Botelho, Marina Tenorio
;
Magalhaes, Gabriel Rampazzo
;
Raisanen, Riikka
;
Freeman, Harold S.
;
Umbuzeiro, Gisela de Aragao
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Food and Chemical Toxicology; v. 189, p. 8-pg., 2024-05-22. |
| Resumo | |
Emodin is an anthraquinone secondary metabolite produced by several species of plants and fungi. Emodin is known for its pharmacological versatility, and, in the textile industry, for its good dyeing properties. However, its use in the textile industry can result in the formation and disposal of large volumes of wastewater. Emodin mutagenicity has been shown in bacteria and in human cells, but little is known about its possible toxic, genotoxic, or mutagenic effects in aquatic organisms. We have evaluated the eco/genotoxicity of emodin to aquatic organisms. Emodin was toxic to Daphnia similis (EC50 = 130 mu g L-1) and zebrafish embryos (LC50 = 25 mu g L-1). No toxicity was observed for Raphidocelis subcapitata, Ceriodaphnia dubia, or Parhyale hawaiensis. Additional biochemistry/molecular studies are needed to elucidate the toxic/mutagenic pathways of emodin in aquatic organisms. The PNEC value for emodin was 0.025 mu g L-1. In addition to mutagenicity in the Salmonella/ microsome assay, emodin was mutagenic in the micronucleus assay in the amphipod P. hawaiensis. Among the anthraquinone dyes tested to date, natural or synthetic, emodin was the most toxic to aquatic species. (AU) | |
| Processo FAPESP: | 20/04628-8 - ToxBioColour: toxicologia de corantes naturais para um ambiente sustentável |
| Beneficiário: | Gisela de Aragão Umbuzeiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/06369-2 - Avaliação da eco/genotoxicidade de um corante natural modificado para processos sustentáveis |
| Beneficiário: | Gabriel Rampazzo Magalhães |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 23/07768-3 - Toxicidade e mutagenicidade do corante natural alizarina |
| Beneficiário: | Amanda Rocha Rodrigues |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 22/04482-9 - Desenvolvendo o anfípode marinho Parhyale hawaiensis como uma nova plataforma para avaliação mutagênica de células germinativas |
| Beneficiário: | Marina Tenório Botelho |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |