| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza Vieira, Gustavo
;
de Carvalho Kimura, Talita
;
Scarini, Joao Figueira
;
de Lima-Souza, Reydson Alcides
;
Lavareze, Luccas
;
Emerick, Carolina
;
Goncalves, Mayara Trevizol
;
Damas, Ingrid Iara
;
Figueiredo-Maciel, Tayna
;
de Sa, Raisa Sales
;
Aquino, Iara Goncalves
;
de Paiva, Joao Paulo Goncalves
;
Fernandes, Patricia Maria
;
Goncalves, Moises Willian Aparecido
;
Kowalski, Luiz Paulo
;
Altemani, Albina
;
Fillmore, Gary Chris
;
Mariano, Fernanda Viviane
;
Abu Egal, Erika Said
Número total de Autores: 19
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CYTOKINE; v. 173, p. 17-pg., 2023-11-07. |
| Resumo | |
Colony-stimulating factors (CSFs) are key cytokines responsible for the production, maturation, and mobilization of the granulocytic and macrophage lineages from the bone marrow, which have been gaining attention for playing pro-and/or anti-tumorigenic roles in cancer. Head and neck cancers (HNCs) represent a group of heterogeneous neoplasms with high morbidity and mortality worldwide. Treatment for HNCs is still limited even with the advancements in cancer immunotherapy. Novel treatments for patients with recurrent and metastatic HNCs are urgently needed. This article provides an in-depth review of the role of hematopoietic cytokines such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interleukin-3 (IL-3; also known as multi-CSF) in the HNCs tumor microenvironment. We have reviewed current results from clinical trials using CSFs as adjuvant therapy to treat HNCs patients, and also clinical findings reported to date on the therapeutic application of CSFs toxicities arising from chemoradiotherapy. (AU) | |
| Processo FAPESP: | 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo |
| Beneficiário: | João Figueira Scarini |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/08431-4 - Análise do perfil metabolômico na transformação maligna do adenoma pleomórfico |
| Beneficiário: | Reydson Alcides de Lima Souza |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica |
| Beneficiário: | Fernanda Viviane Mariano Brum Corrêa |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 21/12567-1 - Validação de potenciais alterações genômicas encontradas durante a transformação maligna do adenoma pleomórfico |
| Beneficiário: | João Figueira Scarini |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |