| Texto completo | |
| Autor(es): |
Barreto, Gabriel
;
Esteves, Gabriel p.
;
Marticorena, Felipe
;
Oliveira, Tamires n.
;
Grgic, Jozo
;
Saunders, Bryan
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 56, n. 2, p. 12-pg., 2024-02-01. |
| Resumo | |
Purpose:<bold> </bold>This study aimed to summarize and meta-analyze existing evidence regarding the influence of CYP1A2 genotypes on the acute effects of caffeine for exercise performance and to investigate the interaction between genotype, dosage, and timing of caffeine supplementation. Methods:<bold> </bold>Six databases were searched for studies determining the effect of caffeine (except mouth rinsing) on exercise performance between CYP1A2 genotypes. Three-level meta-analyses were performed using standardized mean differences (SMD; Hedge's g ) to determine the effect of caffeine on exercise outcomes within and between CYP1A2 genotypes (AA, AC, and CC). Meta-regressions were performed for dose, timing, and presence of reported conflict of interests (RCOI). A meta-analysis was also performed with placebo values to assess for imbalances between genotypes. Results: Thirteen studies, totaling 119 outcomes and 440 participants, were included (233 AA, 175 AC, ad 34 CC). Caffeine improved performance for AA (SMD = 0.30, 95% confidence interval [CI] = 0.21-0.39, P < 0.0001) and AC (SMD = 0.16, 95% CI = 0.06-0.25, P = 0.022) but worsened performance for CC (SMD = -0.22, 95% CI = -0.44 to -0.01, P < 0.0001). Dose affected only CC, with greater doses generating more positive SMD (CC-dose estimate: +0.19/1 mg<middle dot>kg -1 body mass, 95% CI = 0.04-0.33, P = 0.01). Timing influenced only CC, with better performance with later onset of exercise after supplementation (CC-timing estimate: +0.01/min, 95% CI = 0.00-0.02, P = 0.02). RCOI only affected SMD of CC (CC-RCOI estimate: -0.57, 95% CI = -1.02 to -0.12, P = 0.01). After excluding studies with RCOI, no influence of genotype was seen (all P >= 0.19). Small, nonsignificant differences were seen in placebo between genotypes (SMD AA vs CC: -0.13; AA vs AC: -0.12; AC vs CC: -0.05; all P >= 0.26). Conclusions: Caffeine improved performance for AA and AC but worsened performance for CC. Dose and timing moderated the efficacy of caffeine for CC only. Caution is advised because baseline differences and studies with RCOI could have influenced these results. (AU) | |
| Processo FAPESP: | 21/12116-0 - Cafeína, genótipos CYP1A2 e desempenho esportivo: apenas uma questão de tempo? |
| Beneficiário: | Gabriel Henrique Castanho Barreto |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |
| Processo FAPESP: | 20/07860-9 - A influência do treinamento físico na saúde óssea de pacientes recebendo doses elevadas de glicocorticoides |
| Beneficiário: | Gabriel Perri Esteves |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 21/05847-8 - Efeito placebo sobre a performance esportiva e cognitiva após o condicionamento à suplementação de cafeína |
| Beneficiário: | Felipe Miguel Marticorena |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 20/12036-3 - A influência do polimorfismo CYP1A2 sobre as respostas fisiológicas e de desempenho após a suplementação aguda de cafeína |
| Beneficiário: | Gabriel Henrique Castanho Barreto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 21/06836-0 - Placebo em esporte e exercício: prevalência, condicionamento e placebo aberto |
| Beneficiário: | Bryan Saunders |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 22/07327-4 - Os efeitos de placebo e placebo aberto em diferentes formas de administração sobre o desempenho, força e hipertrofia |
| Beneficiário: | Tamires Nunes Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |