| Texto completo | |
| Autor(es): |
Lins, Paula Maria Pincela
;
Ribovski, Lais
;
Antonio, Luana Corsi
;
Altei, Wanessa Fernanda
;
Selistre-de-Araujo, Heloisa Sobreiro
;
Cancino-Bernardi, Juliana
;
Zucolotto, Valtencir
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS; v. 176, p. 12-pg., 2022-07-01. |
| Resumo | |
Extracellular vesicles (EVs) and cell membrane nanoghosts are excellent coatings for nanomaterials, providing enhanced delivery in the target sites and evasion of the immune system. These cell-derived coatings allow the exploration of the delivery properties of the nanoparticles without stimulation of the immune system. Despite the advances reported on the use of EVs and cell-membrane coatings for nanomedicine applications, there are no standards to compare the benefits and main differences between these technologies. Here we investigated macrophage-derived EVs and cell membranes-coated gold nanorods and compared both systems in terms of target delivery in cancer and stromal cells. Our results reveal a higher tendency of EV-coated nanorods to interact with macrophages yet both EV and cell membrane-coated nanorods were internalized in the metastatic breast cancer cells. The main differences between these nanoparticles are related to the presence or absence of CD47 in the coating material, not usually addressed in EVs characterization. Our findings highlight important delivery differences exhibited by EVs- or cell membranes- coated nanorods which understanding may be important to the design and development of theragnostic nanomaterials using these coatings for target delivery. (AU) | |
| Processo FAPESP: | 14/50947-7 - INCT 2014: em Células Tronco e Terapia Celular no Câncer |
| Beneficiário: | Dimas Tadeu Covas |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/00124-5 - Nanomateriais funcionalizados para aplicação em terapias contra o câncer |
| Beneficiário: | Valtencir Zucolotto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/21869-6 - Nanomateriais teranósticos revestidos com membrana celular para aplicações em Nanomedicina |
| Beneficiário: | Paula Maria Pincela Lins |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 16/00971-4 - Estudo de endocitose e exocitose de nanomateriais e de exossomos: aplicações em nanomedicina |
| Beneficiário: | Paula Maria Pincela Lins |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |