The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice

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Ramos, Camila de Oliveira ; Sant'Ana, Marcella Ramos ; Goncalves, Giovana Rios ; Rios, Thaiane da Silva ; Nakandakari, Susana Castelo Branco Ramos ; Burger, Beatriz ; Fernandes, Luis Gustavo Romani ; Zollner, Ricardo de Lima ; de Oliveira, Arthur Noin ; Ramos, Rodrigo Catharino ; da Silva, Adelino Sanchez Ramos ; Pauli, Jose Rodrigo ; de Moura, Leandro Pereira ; Ropelle, Eduardo Rochete ; Mansour, Eli ; Cintra, Dennys Esper

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR NUTRITION & FOOD RESEARCH; v. 68, n. 18, p. 14-pg., 2024-08-29.

Resumo

Omega-3 (omega 3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in alpha-linolenic (C18:3 - omega 3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the omega 3 content and, notwithstanding a reduction in the interleukins (IL) IL1 beta and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of omega 3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of omega 3 supplements, warranting caution. The food source of fatty acids immediately reverbs in the lung parenchyma composition. A high-fat diet did not change the pro-inflammatory markers; however, induced pronounced fibrosis. Despite general metabolic improvements, a diet rich in omega 3 induced damage in the lung, followed by an increased alveolar density, changes in the leukotrienes, and a dramatic IL10 reduction, without protecting against lung fibrosis. image (AU)

• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 19/13210-0 - Avaliação do mecanismo molecular de ação dos ácidos graxos ômega-3 no desenvolvimento precoce da Doença de Alzheimer associada à obesidade e Diabetes tipo 2 em camundongos: papel do receptor GPR120
• Beneficiário: Dennys Esper Corrêa Cintra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/18665-0 - Avaliação do Potencial Antiinflamatório dos Ácidos Graxos Ômega-3 Através de seu Receptor GPR120, sobre o Parênquima Pulmonar de Camundongos Obesos e Diabéticos do Tipo 2, Induzidos pelo Consumo de Dieta Rica em Gordura.
• Beneficiário: Camila de Oliveira Ramos
• Modalidade de apoio: Bolsas no Brasil - Doutorado