Physical virology: how physics is enabling a better understanding of recent viral invaders

Autor(es)

Cardoso-Lima, Ruana ; Santos-Oliveira, Ralph ; Souza, Pedro Filho Noronha ; Barbosa, Leandro R. S. ; Wuite, Gijs J. L. ; Alencar, Luciana Magalhes Rebelo

• Tipo de documento: Artigo Científico
• Fonte: BIOPHYSICAL REVIEWS; v. 15, n. 4, p. 13-pg., 2023-08-01.

Resumo

The world is frequently afflicted by several viral outbreaks that bring diseases and health crises. It is vital to comprehend how viral assemblies' fundamental components work to counteract them. Determining the ultrastructure and nanomechanical characteristics of viruses from a physical standpoint helps categorize their mechanical characteristics, offers insight into new treatment options, and/or shows weak spots that can clarify methods for medication targeting. This study compiles the findings from studies on the ultrastructure and nanomechanical behavior of SARS-CoV-2, ZIKV (Zika virus), and CHIKV (Chikungunya virus) viral particles. With results that uncovered aspects of the organization and the spatial distribution of the proteins on the surface of the viral particle as well as the deformation response of the particles when applied a recurring loading force, this review aims to provide further discussion on the mechanical properties of viral particles at the nanoscale, offering new prospects that could be employed for designing strategies for the prevention and treatment of viral diseases. (AU)

• Processo FAPESP: 17/26131-5 - Chaperoma: estudo da relação entre a estrutura dos seus componentes e a manutenção da proteostase
• Beneficiário: Carlos Henrique Inacio Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Temático