Autor(es)

Carvalho, Gabriela Correa ; Marena, Gabriel Davi ; Fernandes, Micaela Gaspar Goncalves ; Leonardi, Gabriela Ricci ; Santos, Helder A. ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: ADVANCED HEALTHCARE MATERIALS; v. 13, n. 22, p. 29-pg., 2024-05-22.

Resumo

Curcumin is a natural product found in the rhizome of Curcuma longa (L.) and other Curcuma spp. As a lipophilic molecule, it has greater affinity for polar, non-polar, alkaline, or extremely acidic organic solvents. Several studies indicate that curcumin has several benefits for human health, for example, against degenerative diseases, cancer, and infectious diseases. To obtain a quality product with nutraceutical properties, it is necessary to know its physicochemical characteristics and preserve it from cultivation until ingestion by the human. However, its low solubility leads to low absorption; in this context, nanotechnological systems can contribute to increase curcumin bioavailability. This review aims to highlight important issues in all stages that curcumin goes through: from aspects related to its extraction to its association with nanotechnology. Although curcumin extraction process is already well established, it is possible to observe more and more research focused on increasing yield and being more environmentally friendly. Further, curcumin's low absorption is notable due to its physicochemical characteristics, mainly due to its low aqueous solubility. However, its association with nanotechnology shows to be promising and an increasingly growing trend because the use of this "Indian solid gold" is the hope of many patients. (AU)

• Processo FAPESP: 22/02187-0 - Sistema nano-in-nano contendo curcumina e cloridrato de benzidamina para o tratamento da candidíase vulvovaginal: do desenvolvimento à aplicação in vitro anti-inflamatória
• Beneficiário: Gabriela Corrêa Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 19/26821-7 - Nano-in-nano contendo curcumina e cloridrato de benzidamina para tratamento de Candidíase Vulvovaginal: do desenvolvimento à aplicação biológica in vitro e in vivo
• Beneficiário: Gabriela Corrêa Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/09831-9 - Nanoemulsões para co-encapsulação de anfotericina B e micafungina: desenvolvimento, caracterização e avaliação do potencial in vitro e in vivo contra Candida auris
• Beneficiário: Gabriel Davi Marena
• Modalidade de apoio: Bolsas no Brasil - Doutorado