| Texto completo | |
| Autor(es): |
Sonoda, Gabriel Gonzalez
;
Tobaruela, Eric de Castro
;
Norenburg, Jon
;
Fabi, Joao Paulo
;
Andrade, Sonia C. S.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TOXINS; v. 15, n. 11, p. 27-pg., 2023-11-01. |
| Resumo | |
Some, probably most and perhaps all, members of the phylum Nemertea are poisonous, documented so far from marine and benthic specimens. Although the toxicity of these animals has been long known, systematic studies on the characterization of toxins, mechanisms of toxicity, and toxin evolution for this group are scarce. Here, we present the first investigation of the molecular evolution of toxins in Nemertea. Using a proteo-transcriptomic approach, we described toxins in the body and poisonous mucus of the pilidiophoran Lineus sanguineus and the hoplonemertean Nemertopsis pamelaroeae. Using these new and publicly available transcriptomes, we investigated the molecular evolution of six selected toxin gene families. In addition, we also characterized in silico the toxin genes found in the interstitial hoplonemertean, Ototyphlonemertes erneba, a meiofaunal taxa. We successfully identified over 200 toxin transcripts in each of these species. Evidence of positive selection and gene duplication was observed in all investigated toxin genes. We hypothesized that the increased rates of gene duplications observed for Pilidiophora could be involved with the expansion of toxin genes. Studies concerning the natural history of Nemertea are still needed to understand the evolution of their toxins. Nevertheless, our results show evolutionary mechanisms similar to other venomous groups. (AU) | |
| Processo FAPESP: | 15/20139-9 - Genética de paisagens marinha e avaliação de perfis de expressão em invertebrados marinhos na costa sudeste brasileira |
| Beneficiário: | Sónia Cristina da Silva Andrade |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 18/12502-4 - Evolução molecular e diversidade genética de toxinas em Nemertea |
| Beneficiário: | Gabriel Gonzalez Sonoda |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 21/06738-8 - Genética de paisagens e genômica comparativa: uma abordagem integrada no estudo evolutivo de invertebrados marinhos |
| Beneficiário: | Sónia Cristina da Silva Andrade |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Jovens Pesquisadores - Fase 2 |
| Processo FAPESP: | 20/06467-1 - Efeito do consumo de compostos bioativos de frutas no metabolismo humano: abordagem metabolômica e proteômica integrada |
| Beneficiário: | Eric de Castro Tobaruela |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |