| Texto completo | |
| Autor(es): |
Gantner, Benjamin N.
;
Palma, Flavio R.
;
Kayzuka, Cezar
;
Lacchini, Riccardo
;
Foltz, Daniel R.
;
Backman, Vadim
;
Kelleher, Neil
;
Shilatifard, Ali
;
Bonini, Marcelo G.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | TRENDS IN GENETICS; v. 40, n. 9, p. 8-pg., 2024-09-09. |
| Resumo | |
The emergence of aerobic respiration created unprecedented bioenergetic advantages, while imposing the need to protect critical genetic information from reactive byproducts of oxidative metabolism (i.e., reactive oxygen species, ROS). The evolution of histone proteins fulfilled the need to shield DNA from these potentially damaging toxins, while providing the means to compact and structure massive eukaryotic genomes. To date, several metabolism-linked histone post-translational modifications (PTMs) have been shown to regulate chromatin structure and gene expression. However, whether and how PTMs enacted by metabolically produced ROS regulate adaptive chromatin remodeling remain relatively unexplored. Here, we review novel mechanistic insights into the interactions of ROS with histones and their consequences for the control of gene expression regulation, cellular plasticity, and behavior. (AU) | |
| Processo FAPESP: | 20/11740-9 - Avaliação dos mecanismos epigenéticos na resposta a tratamentos farmacológicos nos genes relacionados à Hipertensão Arterial em modelo experimental animal |
| Beneficiário: | Cezar Kayzuka Cotta Filho |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 22/07921-3 - Lesão vascular pulmonar associada ao envelhecimento via estresse oxidativo mediado por NOS1/3 |
| Beneficiário: | Cezar Kayzuka Cotta Filho |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto |