Semaphorins and the bone marrow microenvironment: New candidates that influence the hematopoietic system

Autor(es)

Goncalves, Carlos E. da Silva ; Fock, Ricardo A.

• Tipo de documento: Artigo Científico
• Fonte: CYTOKINE & GROWTH FACTOR REVIEWS; v. 76, p. 8-pg., 2024-03-25.

Resumo

The bone marrow is a haven for hematopoietic and non-hematopoietic cells, creating complex micro-anatomical regions called niches. These distinct niches all participate in an intricate orchestra of cellular interactions that regulates the hematopoietic stem cell and its progenies. In this review, we provide a detailed description of the three most well-known bone marrow niches and their participation in hematopoiesis. We use pre-clinical data, including different in vitro and in vivo studies to discuss how a group of proteins called Semaphorins could potentially modulate both hematopoietic and non-hematopoietic cells, establishing links between the niches, semaphorins, and hematopoietic regulation. Thus, here we provide a deep dive into the inner functioning of the bone marrow and discuss the overarching implications that semaphorins might have on blood formation. (AU)

• Processo FAPESP: 23/03938-1 - Avaliação dos efeitos da desnutrição proteica e da renutrição sob aspectos de controle da hematopoese: participação das semaforinas classe 3 e 4
• Beneficiário: Carlos Eduardo da Silva Gonçalves
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/08658-1 - Influência da desnutrição proteica em idosos sobre aspectos imunomodulatórios das células estromais mesenquimais medulares e sua ação na regulação da hematopoese
• Beneficiário: Ricardo Ambrósio Fock
• Modalidade de apoio: Auxílio à Pesquisa - Regular